Two sample MR report
ERAP2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 9 | -0.0083505 | 0.2250189 | 0.9714331 |
| Weighted median | 9 | -0.0583235 | 0.0194244 | 0.0026769 |
| Inverse variance weighted | 9 | -0.0572475 | 0.0156069 | 0.0002444 |
| Simple mode | 9 | -0.0589028 | 0.0279548 | 0.0681832 |
| Weighted mode | 9 | -0.0587022 | 0.0286435 | 0.0745770 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.8541061 | 7 | 0.9968518 |
| Inverse variance weighted | 0.9015544 | 8 | 0.9987971 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.032999 | 0.151492 | 0.833778 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003282 | 0 | TRUE | 0.0852522 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
